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KMID : 1134820200490121309
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 12 p.1309 ~ p.1318
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Immuno-Enhancing and Anticancer Effects of Sweet Potato Peel-Based Plant Mixture
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Jeong In-Seon
Kang Kyeong-Sun
Kim Eiun-Hye
Park Seung-Man
Chung Mi-Ja
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Abstract
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This study investigated the immune-enhancing activity and anticancer effects of a sweet potato peel-based plant mixture, including Platycodon grandiflorum, Codonopsis lanceolata and corn silk, on RAW264.7 macrophages or AGS human gastric cancer cells. The products developed in this study were pouches (M3E-A) made by plant mixture extract, stick pouches (M3C-B) made using M3E-A concentrate and plant mixture tea (M3T-C). The M3A, M3B, and M3C were in the form of freeze-dried powder after the extraction and concentration of M3E-A, M3C-B, and M3T-C, respectively. The M3A, M3B, and M3C dose-dependently increased the production of nitric oxide (NO) and pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-6 in RAW264.7 macrophages. The NO and cytokine (TNF-α, IL-1β, and IL-6) levels in the M3A or M3C-treated RAW264.7 macrophages were higher than those in the M3B-treated RAW264.7 macrophages. Mice treated orally with M3C (100 mg/kg, 300 mg/kg), resulted in significantly increased splenocyte proliferation, NO levels and cytokine (INF-γ, IL-10) levels compared to control mice. The M3A, M3B, and M3C (250 to 2,000 μg/mL), respectively, inhibited the growth of AGS cells in a dose-dependent manner. These results indicate that products using sweet potato peel-based plant mixture may be used for immuno-enhancing and anticancer effects by healthy people and cancer patients.
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KEYWORD
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AGS cells, anticancer effect, immuno-enhancing effect, mouse, RAW264, 7 macrophages
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